αS1-CnD, another allele associated with a decreased synthesis rate at the caprine αS1-casein locus
نویسندگان
چکیده
منابع مشابه
The Membrane-Associated Form of αs1-Casein Interacts with Cholesterol-Rich Detergent-Resistant Microdomains
Caseins, the main milk proteins, interact with colloidal calcium phosphate to form the casein micelle. The mesostructure of this supramolecular assembly markedly influences its nutritional and technological functionalities. However, its detailed molecular organization and the cellular mechanisms involved in its biogenesis have been only partially established. There is a growing body of evidence...
متن کاملAutoantibodies to αS1-Casein Are Induced by Breast-Feeding
BACKGROUND The generation of antibodies is impaired in newborns due to an immature immune system and reduced exposure to pathogens due to maternally derived antibodies and placental functions. During nursing, the immune system of newborns is challenged with multiple milk-derived proteins. Amongst them, caseins are the main constituent. In particular, human αS1-casein (CSN1S1) was recently shown...
متن کاملAllergic responses induced by goat milk αS1-casein in a murine model of gastrointestinal atopy.
Up to 3% of young children develop milk allergy and this may influence the development of immune-mediated diseases in later life. One protein that has been associated with allergic reactions to ruminant milk is α(S1)-casein (CN). Studies suggest that goat milk with low levels of α(S1)-CN may reduce allergenicity of milk, but the dose response to α(S1)-CN has not been confirmed. In this study, w...
متن کاملContributions of Terminal Peptides to the Associative Behavior of αs1-Casein
The Nand C-terminal segments of bovine αs1-caseinB (f1-23 and f136-196) were characterized under conditions that promoted or inhibited self-association to determine the relative contributions of each fragment to the interaction of αs1-casein with itself or with other caseins. In earlier studies of f1-23, nuclear magnetic resonance (NMR) data and circular dichroism (CD) spectra showed that its c...
متن کاملMutational analysis of major IgE-binding epitopes of recombinant bovine αS1-casein
Background Cow’s milk allergy (CMA) is one of the most widespread human allergies, especially in very young children. One of the main bovine milk allergen is aS1-casein which is considered as intrinsically unfolded protein. Its epitope determinants have been partially characterized using synthetic peptides and crucial amino acid residues for IgE-binding have been identified. However, this very ...
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ژورنال
عنوان ژورنال: Genetics Selection Evolution
سال: 1989
ISSN: 0754-0264
DOI: 10.1051/gse:19890202